The lone star tick is considered a three-host tick because each feeding stage requires a different host. Feeding typically occurs during the spring and early summer months. Larvae and nymphs feed on the blood of birds, rodents and small wild animals like rabbits, squirrels and raccoons. Adults often feed on larger animals, including foxes, dogs, white-tailed deer and humans. This tick species then enters a non-feeding period in mid to late summer, which is triggered by decreasing day length.
Lone star ticks cannot survive long exposures to sunlight, so they are typically found in shaded, wooded areas with low-growing vegetation.
All three developmental stages of the lone star tick can feed on humans by attaching to the skin using its mouthparts. This tick can be a vector of tularemia, Rocky Mountain spotted fever and ehrlichiosis.